'From fever to freeze: documenting paracetamol-induced hypothermia in a child'

Area of Science:

• Pediatrics
• Pharmacology
• Clinical Toxicology

Background:

• Paracetamol (acetaminophen) is a widely used antipyretic in pediatric populations.
• While generally safe, rare adverse effects like paradoxical hypothermia can occur.
• Understanding these rare reactions is crucial for patient safety.

Purpose of the Study:

• To report a case of paradoxical hypothermia in a child following standard-dose paracetamol administration.
• To emphasize the importance of recognizing rare adverse drug reactions.
• To suggest potential management strategies for such events.

Main Methods:

• A case report of a pediatric patient experiencing adverse effects after paracetamol intake.
• Clinical monitoring and investigation to rule out other causes of hypothermia.
• Observation of patient response to dose adjustments.

Main Results:

• The child developed significant hypothermia after receiving standard oral doses of paracetamol.
• No alternative causes for the hypothermia were identified.
• The child tolerated lower doses of paracetamol without recurrence of hypothermia.

Conclusions:

• Paradoxical hypothermia is a rare but possible adverse effect of paracetamol in children.
• Conservative management and cautious re-administration with lower doses may be effective.
• This case highlights the need for vigilance regarding uncommon drug reactions.