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Basic Science and Pathogenesis.

Pardeep Kumar1

  • 1F H Medical College & Hospital, Agra, Uttar Pradesh, India.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

Dehydroepiandrosterone (DHEA) supplementation improved cognitive function and reversed age-related molecular changes in aging rats. This neurosteroid shows promise as an anti-aging therapy for neuronal decline.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Biochemistry

Background:

  • Dehydroepiandrosterone (DHEA), a neurosteroid, declines with age, increasing neuronal vulnerability.
  • Aging impacts neurotransmitter systems, glucose metabolism, and cellular integrity.
  • This study investigates DHEA's neuroprotective effects against age-related brain changes.

Purpose of the Study:

  • To evaluate DHEA's impact on neurochemical markers in aging rats.
  • To assess DHEA's effects on cognitive performance and brain molecular profiles.
  • To determine if DHEA can restore age-diminished parameters to youthful levels.

Main Methods:

  • Aged male rats received daily DHEA injections for one month.
  • Biochemical and molecular analyses were performed on isolated synaptosomes.
  • Cognitive function was assessed using the Morris water maze; ultrastructural changes were evaluated via MRI.

Main Results:

  • DHEA treatment improved cognitive performance and memory in aged rats.
  • DHEA administration normalized levels of acetylcholinesterase (ACh), tyrosine hydroxylase (TyrH), and glucose transporter 4 (GLUT4).
  • Reduced neurolipofuscin accumulation and increased superoxide dismutase (SOD) activity were observed post-DHEA treatment.

Conclusions:

  • DHEA exhibits significant neuroprotective and anti-aging properties.
  • DHEA effectively counteracts age-associated molecular and behavioral deficits in the brain.
  • DHEA holds potential as an adjunct therapy for age-related neuronal decline.