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Basic Science and Pathogenesis.

Geidy E Serrano1, Sidra Aslam2, Jessica Walker1

  • 1Banner Sun Health Research Institute, Sun City, AZ, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

Hispanic individuals show increased Alzheimer's disease dementia (ADD) neuropathology and vascular risk factors compared to non-Hispanics. Further research is needed to understand the intersection of race and ethnicity in these findings.

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Area of Science:

  • Neuropathology
  • Neurodegenerative Diseases
  • Vascular Biology

Background:

  • Hispanics may have a higher risk of Alzheimer's disease dementia (ADD).
  • Limited neuropathologically validated studies exist for this demographic.
  • This study addresses the need for more in-depth neuropathological research in Hispanic populations.

Purpose of the Study:

  • To compare neuropathological changes in Hispanic brain donors with non-Hispanic donors.
  • To investigate the prevalence of Alzheimer's disease dementia (ADD) and vascular pathology in Hispanic individuals.
  • To analyze demographic and clinical factors associated with neuropathological findings in Hispanics.

Main Methods:

  • Utilized data from the National Alzheimer's Coordinating Center (NACC) repository.
  • Included over 2,100 Hispanic participants with brain donations and neuropathological evaluations.
  • Compared neuropathological findings between Hispanic and non-Hispanic participants.

Main Results:

  • Hispanic participants exhibited higher rates of intermediate to high Alzheimer's disease dementia (ADD) neuropathological changes (75% vs. 67%).
  • Increased severity of vascular pathology, including cerebral amyloid angiopathy and white matter rarefaction, was observed in Hispanics.
  • Hispanic individuals presented with higher prevalence of cardiovascular risk factors like hypertension and diabetes.

Conclusions:

  • Findings align with previous studies indicating greater white matter hyperintensity and vascular risk factors in Hispanic populations.
  • The study highlights significant neuropathological differences between Hispanic and non-Hispanic individuals.
  • Further research is recommended to explore the complex interplay between race and ethnicity in Alzheimer's disease dementia (ADD).