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Published on: June 14, 2020
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Basic Science and Pathogenesis.
Chenyang Li1, Dominique Leitner1, Huize Pang1
1NYU Grossman School of Medicine, New York, NY, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
This study links white matter hyperintensities (WMH) MRI signals to specific brain pathologies in Alzheimer's disease. High-resolution MRI and histology reveal WMH signal origins, improving in vivo interpretation.
Area of Science:
- Neuroimaging
- Neuropathology
- Alzheimer's Disease and Related Dementias (AD/ADRD)
Background:
- White matter hyperintensities (WMHs) are key MRI biomarkers in AD/ADRD.
- Histopathology links WMHs to demyelination and neuroinflammation.
- Direct correlation between in vivo MRI and histopathology is challenging.
Purpose of the Study:
- To bridge clinical MRI findings of WMHs with histopathological data.
- To utilize multiparametric and multiscale MRI in dementia brains.
- To quantitatively correlate in vivo MRI signals with specific histopathological features.
Main Methods:
- Inclusion of two post-mortem AD brains.
- Sequential 3T MRI acquisitions (whole-hemisphere and high-resolution ex vivo).
- Sectioning of brain tissue blocks for imaging and histology.
Main Results:
- Postmortem WMH contrast comparable to in vivo imaging.
- WMHs showed increased mean diffusivity (MD) and prolonged T1, T2, T2* relaxation times.
- Histopathology confirmed spatial overlap and revealed vacuolation, demyelination, astrogliosis, and neuroinflammation.
Conclusions:
- Joint analysis of postmortem MRI and histopathology reveals complex WMH signal origins.
- Elevated diffusivity and prolonged relaxation times correlate with histological findings.
- Provides insights into the in vivo signal composition of WMHs.
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