Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

40.0K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
40.0K
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

3.5K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling.

Journal of periodontal research·2026
Same author

Local Sodium Tanshinone IIA Sulfonate Attenuates Periodontal Bone Loss by Modulating Inflammatory, Immune and Osteoclastogenic Signalling.

Journal of clinical periodontology·2026
Same author

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation.

Advanced healthcare materials·2026
Same author

Impact of prosthetic abutment design on peri-implant clinical and esthetic outcomes: A systematic review and meta-analysis of randomized controlled trials.

Journal of prosthodontics : official journal of the American College of Prosthodontists·2026
Same author

Impact of oral biotin supplementation on periodontal disease progression and therapy in male rats.

Archives of oral biology·2026
Same author

Modulation of TLR4, hBD-2, and hBD-3 expression and hepatic tissue response by systemic probiotics in experimental apical periodontitis in rats.

Journal of applied oral science : revista FOB·2026
Same journal

Removal of Codispersible Residual Impurities from CuInS<sub>2</sub>/ZnS Quantum Dots for Window-Replaceable Luminescent Solar Concentrators.

ACS applied materials & interfaces·2026
Same journal

Durable Core-Shell Scatterer Coating with Heat Storage for Radiative Cooling.

ACS applied materials & interfaces·2026
Same journal

Calix[6]arene-Based Interlocked Inverse Vulcanizate Enabling Network-Interface Cooperative Reinforcement in Natural Rubber/Carbon Black Composites.

ACS applied materials & interfaces·2026
Same journal

Resolving Thermal Accumulation and Rigid-Soft Interface Mismatch in Stretchable Electronics with Cubic Boron Nitride Composite Islands.

ACS applied materials & interfaces·2026
Same journal

Enhancing Conversion Reversibility and Initial Coulombic Efficiency of SnO<sub>2</sub> Anodes via NiO/Ni-Carbon Interfacial Design.

ACS applied materials & interfaces·2026
Same journal

Multidimensional Interface Structure Design for High-Efficiency Optically Controlled Semiconductor Devices: A Case Study on Memristive Synapses.

ACS applied materials & interfaces·2026
See all related articles

Related Experiment Video

Updated: Jan 8, 2026

Animal Model of Implant-Associated Infections in Mice
07:02

Animal Model of Implant-Associated Infections in Mice

Published on: June 27, 2025

784

Targeted Infection Control and Tissue Integration via pH-Sensitive Smart Coatings on Implant Surfaces.

Marta Maria Alves Pereira1,2, Rodolfo Debone Piazza3, Paula Aboud Barbugli1

  • 1Department of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, São Paulo 14801-903, Brazil.

ACS Applied Materials & Interfaces
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

A novel stimuli-responsive coating for titanium implants delivers drugs to fight infection and inflammation. This smart coating enhances tissue integration and shows promising antimicrobial and anti-inflammatory effects for better implant outcomes.

Keywords:
antimicrobial coatingdrug delivery systemimplantsmart coatingstimuli-responsive biomaterial

More Related Videos

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes
06:39

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes

Published on: June 8, 2022

2.7K
High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

9.4K

Related Experiment Videos

Last Updated: Jan 8, 2026

Animal Model of Implant-Associated Infections in Mice
07:02

Animal Model of Implant-Associated Infections in Mice

Published on: June 27, 2025

784
Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes
06:39

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes

Published on: June 8, 2022

2.7K
High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

9.4K

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Implantology

Background:

  • Peri-implant infections and inflammation pose significant challenges for titanium (Ti) implants.
  • Current treatments often lack localized control and can lead to adverse effects.
  • Need for advanced coatings that provide targeted drug delivery and promote tissue integration.

Purpose of the Study:

  • To develop and evaluate a stimuli-responsive drug delivery coating for Ti implants.
  • To assess the coating's ability to control drug release, exhibit antimicrobial activity, and promote soft tissue sealing.
  • To investigate the coating's cytocompatibility and in vivo immunomodulatory effects.

Main Methods:

  • Fabrication of a layer-by-layer (LbL) coating incorporating tetracycline (TC) complexed with beta cyclodextrin (βCD) and a pH-responsive poly(methacrylic acid) (PMAA) film.
  • Characterization of coating properties including drug release, hydrophilicity, and surface roughness.
  • In vitro cytocompatibility assays using cell cultures and collagen matrices.
  • Antibacterial efficacy testing against human saliva-derived biofilms.
  • In vivo evaluation in a rat subcutaneous model to assess immune response.

Main Results:

  • The LbL/TCβCD/PMAA coating demonstrated controlled drug release and favorable surface properties.
  • No cytotoxic effects were observed in in vitro studies; enhanced cellular interactions were noted.
  • Broad-spectrum antimicrobial activity was confirmed against key pathogens in dental implant infections.
  • In vivo studies showed significantly reduced inflammation, increased collagen deposition, and elevated CD206 expression, indicating tissue repair.

Conclusions:

  • The stimuli-responsive coating effectively delivers drugs locally to combat infection and inflammation.
  • The coating promotes favorable cellular interactions and enhances soft tissue integration.
  • This advanced coating strategy holds promise for improving Ti implant performance and patient outcomes.