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Updated: Jan 8, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Photoenzymatic catalysis enables enantioselective radical dearomative spirocyclization

Changtong Zhu1, Yan Zhang2, Zhiwei Deng1

  • 1Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, PR China.

Nature Communications
|December 23, 2025
PubMed
Abstract

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