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A label-free fluorescent probe for deferiprone quantification in exhaled breath condensate utilizing UiO-66
Nima Sheikh Abdollahzadeh Mamaghani1, Zahra Karimzadeh2, Maryam Khoubnasabjafari3,4
1Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:
This study developed a simple and label-free fluorescent probe for deferiprone quantification in exhaled breath condensate (EBC) samples. For that, UiO-66, synthesized in a one-step process with the solvothermal method, along with ferric ions, provided a selective system for deferiprone detection. Deferiprone formed a complex with ferric ions, and the resulting complex quenched the fluorescence intensity of UiO-66 through an inner filter effect process. The probe demonstrated good sensitivity, with a detection limit of 0.005 mg.L- 1 and a linear range of 0.016-1.0 mg.L- 1, and performed reliably in the analysis of deferiprone in EBC samples of the patients.
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