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Updated: Jul 15, 2026

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

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Published on: September 16, 2020

Spatial interaction between retinal and choroidal circulation in retinal vein occlusion.

SolAh Han¹, Sang Uk Choi¹, Yoon Jeon Kim¹

¹Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Scientific Reports

|December 23, 2025

Summary

Retinal vein occlusion (RVO) causes significant choroidal structural changes, including increased thickness and vascularity, particularly in affected areas. These findings highlight localized interactions between retinal and choroidal circulation in RVO.

Keywords:

Choroidal vascular density Choroidal vascular fractal dimension Choroidal vascular remodeling Retinal vein occlusion Ultra-widefield imaging

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Last Updated: Jul 15, 2026

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Area of Science:

Ophthalmology
Vascular Biology
Medical Imaging

Background:

Retinal vein occlusion (RVO) is a major cause of vision loss.
The interplay between retinal and choroidal circulation in RVO is not fully understood.

Purpose of the Study:

To quantitatively assess choroidal structural alterations in treatment-naïve unilateral RVO.
To investigate the localized effects of RVO on choroidal vasculature.

Main Methods:

Retrospective, cross-sectional study of 29 patients with unilateral RVO.
Ultra-widefield imaging including swept-source optical coherence tomography (SS-OCT) and ultra-widefield indocyanine green angiography (UWF-ICGA).
Analysis of mean choroidal thickness (MCT), choroidal vascular index (CVI), choroidal vascular density (CVD), and choroidal vascular fractal dimension (CFD).

Main Results:

RVO eyes showed significantly increased MCT, CVI, and CVD compared to fellow eyes.
Choroidal vascular fractal dimension (CFD) was significantly reduced in RVO eyes.
In branch RVO, choroidal vascular changes (higher CVD, lower CFD) were localized to the affected quadrant.

Conclusions:

RVO induces regional choroidal vascular remodeling.
Findings suggest a localized interaction between retinal and choroidal circulation in acute RVO.
VEGF-driven vasodilation and inflammation may mediate these changes.