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Spatial interaction between retinal and choroidal circulation in retinal vein occlusion.
SolAh Han1, Sang Uk Choi1, Yoon Jeon Kim1
1Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Scientific Reports
|December 23, 2025
Summary
Retinal vein occlusion (RVO) causes significant choroidal structural changes, including increased thickness and vascularity, particularly in affected areas. These findings highlight localized interactions between retinal and choroidal circulation in RVO.
Area of Science:
- Ophthalmology
- Vascular Biology
- Medical Imaging
Background:
- Retinal vein occlusion (RVO) is a major cause of vision loss.
- The interplay between retinal and choroidal circulation in RVO is not fully understood.
Purpose of the Study:
- To quantitatively assess choroidal structural alterations in treatment-naïve unilateral RVO.
- To investigate the localized effects of RVO on choroidal vasculature.
Main Methods:
- Retrospective, cross-sectional study of 29 patients with unilateral RVO.
- Ultra-widefield imaging including swept-source optical coherence tomography (SS-OCT) and ultra-widefield indocyanine green angiography (UWF-ICGA).
- Analysis of mean choroidal thickness (MCT), choroidal vascular index (CVI), choroidal vascular density (CVD), and choroidal vascular fractal dimension (CFD).
Main Results:
- RVO eyes showed significantly increased MCT, CVI, and CVD compared to fellow eyes.
- Choroidal vascular fractal dimension (CFD) was significantly reduced in RVO eyes.
- In branch RVO, choroidal vascular changes (higher CVD, lower CFD) were localized to the affected quadrant.
Conclusions:
- RVO induces regional choroidal vascular remodeling.
- Findings suggest a localized interaction between retinal and choroidal circulation in acute RVO.
- VEGF-driven vasodilation and inflammation may mediate these changes.
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