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Can vascular biomarkers be used in hypertension management to improve cardiovascular outcomes?

Tomoyuki Kabutoya1

  • 1Division of Cardiovascular Medicine, Department of Medicine, and Adult Congenital Heart Disease Center, Jichi Medical University School of Medicine, Shimotsuke, Japan.

Expert Review of Cardiovascular Therapy
|December 23, 2025
PubMed

Insights

Vascular biomarkers help predict cardiovascular events in hypertension. Current guidelines lack clear reference values for blood biomarkers, necessitating further research for improved patient outcomes.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Biomarker Analysis

Background:

  • Vascular biomarkers are established indices of atherosclerosis.
  • Their measurement aids in risk stratification and prognostic prediction for hypertensive patients.
  • These biomarkers are incorporated into various hypertension management guidelines.

Purpose of the Study:

  • To review the evidence for vascular biomarkers in clinical hypertension practice.
  • To discuss the interpretation of these biomarkers within current guidelines.
  • To outline future perspectives and research directions.

Main Methods:

  • Review of existing literature on vascular biomarkers in hypertension.
  • Analysis of current hypertension guidelines regarding biomarker interpretation.
  • Discussion of expert opinions on future research needs.

Main Results:

  • While physiological vascular tests have defined cutoff values in some guidelines, blood biomarker reference values remain unclear.
  • There is an ongoing need for evidence demonstrating the impact of vascular biomarker measurements on patient outcomes.
  • Further research is expected to establish appropriate cutoff values for blood biomarkers and the cardio-ankle vascular index.

Conclusions:

  • Clearer definition and validation of vascular biomarkers are crucial for effective hypertension management.
  • Future studies should focus on establishing evidence-based cutoff values for blood biomarkers to enhance risk stratification.
  • The integration of advanced vascular assessments like the cardio-ankle vascular index holds promise for improved prognostic prediction.
Abstract

Keywords:
C-reactive proteinHypertensionarterial stiffnesscardio-ankle vascular indexendothelial dysfunctionendothelial function testinggrowth differentiation factor-15pulse wave velocity

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