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Modified Single-Loop Reconstruction for Pancreaticoduodenectomy
Published on: September 28, 2019
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Risk factors for 90-day mortality after pancreaticoduodenectomy
Mesut Yur1, Erhan Aygen2, Yavuz Selim İlhan3
1Department of Surgical Oncology, Fırat University, Elazığ, Turkey. myur@firat.edu.tr.
BMC Surgery
|December 23, 2025
Summary
Pancreaticoduodenectomy (PD) for periampullary cancer carries high mortality risks. The MELD-Na score, ACCI, and NLR independently predict 90-day mortality, suggesting targeted interventions can improve outcomes.
Area of Science:
- Surgical Oncology
- Gastroenterology
- Critical Care Medicine
Background:
- Pancreaticoduodenectomy (PD) is a critical surgery for periampullary cancers.
- High postoperative mortality rates necessitate identifying predictive risk factors.
- This study investigates predictors of 90-day mortality following PD.
Purpose of the Study:
- To identify significant risk factors associated with 90-day mortality after PD.
- To evaluate the prognostic value of MELD-Na score, ACCI, and NLR in PD patients.
Main Methods:
- Retrospective analysis of 105 patients undergoing PD between 2010 and 2022.
- Data collected included demographics, pathology, laboratory results, MELD-Na score, ACCI, and NLR.
- Kaplan-Meier analysis and Cox proportional hazards models were used to determine prognostic factors.
Main Results:
- Univariate analysis showed age, sex, albumin, NLR, MELD-Na, and ACCI were associated with mortality (p<0.05).
- Multivariate analysis identified MELD-Na score (HR: 10.75), ACCI (HR: 9.30), and NLR (HR: 7.81) as independent predictors of 90-day mortality (p<0.005).
- These factors significantly increased the risk of postoperative death.
Conclusions:
- MELD-Na score, ACCI, and NLR are independent risk factors for 90-day mortality post-PD.
- Early identification and separate management of high-risk patients by a multidisciplinary team are recommended.
- This approach may help reduce postoperative mortality rates.
