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Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
Published on: June 14, 2020
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Basic Science and Pathogenesis.
Qiong Wang1,2, Duntao Huang2, Linbin Dai1,2
1Department of Neurology, Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
Sodium oligomannate improves cognitive function in Alzheimer's disease (AD) models by reducing neuroinflammation, amyloid plaques, and tau pathology. It also enhances DNA repair pathways and inhibits the cGAS-STING pathway, offering a potential therapeutic mechanism for AD.
Area of Science:
- Neuroscience
- Pharmacology
- Genetics
Background:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline.
- Sodium oligomannate has shown therapeutic potential in AD mouse models and patients, but its underlying mechanisms are not fully understood.
Purpose of the Study:
- To elucidate the molecular mechanisms of sodium oligomannate in Alzheimer's disease.
- To evaluate the effects of sodium oligomannate on cognitive function, AD pathology, and molecular pathways in AD mouse models and patients.
Main Methods:
- Treatment of 5xFAD and APPNL-G-F AD mouse models with sodium oligomannate or vehicle.
- Behavioral tests, AD pathology assessment, and bulk RNA sequencing in mouse models.
- Observation of blood indicators in AD patients treated with sodium oligomannate.
Main Results:
- Sodium oligomannate rescued spatial learning and memory, reduced amyloid plaques, tau phosphorylation, and neuroinflammation in AD mouse models.
- RNA sequencing revealed reversal of neuroinflammation, type I interferon signaling, and upregulation of DNA repair genes.
- Sodium oligomannate alleviated DNA damage and inhibited the cGAS-STING-type I interferon pathway, with consistent findings in AD patients' peripheral blood.
Conclusions:
- Sodium oligomannate exerts therapeutic effects in Alzheimer's disease by modulating neuroinflammation, DNA damage, and related signaling pathways.
- These findings provide mechanistic insights into the efficacy of sodium oligomannate for Alzheimer's disease treatment.
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