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Trends in Acute Myocardial Infarction Mortality Among Patients With Chronic Kidney Disease in the United States

Muhammad Shaheer Bin Faheem1, Syed Tawassul Hassan2, Syeda Umbreen Munir2

  • 1From the Department of Cardiology, Karachi Institute of Medical Sciences, KIMS, Karachi, Sindh, Pakistan.

Cardiology in Review
|December 24, 2025
PubMed

Insights

Mortality from acute myocardial infarction (AMI) in chronic kidney disease (CKD) patients declined overall but shows persistent disparities. Targeted interventions are needed for high-risk groups like males and nonmetropolitan residents.

Area of Science:

  • Cardiology
  • Nephrology
  • Epidemiology

Background:

  • Chronic kidney disease (CKD) is a significant risk factor for acute myocardial infarction (AMI) and adverse cardiovascular outcomes.
  • Understanding long-term mortality trends in CKD patients is crucial for public health strategies.

Purpose of the Study:

  • To analyze long-term trends in AMI mortality among US adults with CKD from 1999 to 2024.
  • To identify demographic and geographic disparities in AMI mortality within the CKD population.

Main Methods:

  • Utilized the CDC's Wide-ranging Online Data for Epidemiologic Research (WONDER) database.
  • Analyzed death certificates for individuals aged ≥45 years with AMI as the underlying cause and CKD as contributing.
  • Calculated age-adjusted mortality rates (AAMRs) and used Joinpoint regression for trend analysis.

Main Results:

  • A total of 81,465 deaths were identified. The overall AAMR decreased from 4.5 in 1999 to 1.5 in 2024.
  • Males, non-Hispanic African Americans, and older adults (≥65 years) exhibited higher AAMRs.
  • Nonmetropolitan areas and the Western US showed elevated AMI mortality rates among CKD patients.

Conclusions:

  • Despite an overall decline, significant disparities in AMI mortality persist among CKD patients based on age, sex, race/ethnicity, and location.
  • Targeted and equitable interventions are necessary to mitigate the mortality burden in high-risk CKD populations.

Keywords:
CDC WONDERacute myocardial infarctionchronic kidney diseasemortality

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