Multi-omics in cardiac arrest: a systematic review

Cardiac arrest (CA) poses significant public health challenges, with high incidence and mortality rates. Characterized by its rapid progression and high mortality, there is a lack of effective pharmacotherapy for CA, making prevention and early intervention crucial. Advancements in genomics, transcriptomics, proteomics, and metabolomics offer profound insights into the pathophysiology and etiology of CA, potentially leading to novel diagnostic biomarkers and therapeutic targets. This comprehensive review explores recent advancements in omics technologies and their applications in understanding CA, highlighting the role of genetic variations, RNA transcripts, protein profiles, and metabolites in CA. It also addresses the limitations of current studies and proposes future directions for omics research in unraveling the complexities of CA. This review aims to advance our understanding of CA and pave the way for precision treatment strategies. Systematic review registration: INPLASY202540024.