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Multi-omics in cardiac arrest: a systematic review.

Huaqing Ye¹, Kaiyi Wang^2,3,4,5,6, Wentao Sang^2,3,4,5,6

¹Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Resuscitation Plus

|December 24, 2025

Summary

Cardiac arrest (CA) research is advancing with omics technologies. These studies offer new insights into CA causes and potential precision treatments, improving patient outcomes.

Keywords:

Biomarkers Cardiac arrest Integrative analysis Omics Precision medicine

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Area of Science:

Cardiology
Genomics
Proteomics
Metabolomics

Background:

Cardiac arrest (CA) presents a major public health issue with high mortality rates.
Current pharmacotherapy for CA is limited, emphasizing the need for prevention and early intervention.
Omics technologies provide novel insights into CA pathophysiology.

Purpose of the Study:

To review recent advancements in omics technologies for understanding CA.
To highlight the role of genetic variations, RNA transcripts, protein profiles, and metabolites in CA.
To identify potential diagnostic biomarkers and therapeutic targets for CA.

Main Methods:

Comprehensive literature review of omics studies related to cardiac arrest.
Analysis of data from genomics, transcriptomics, proteomics, and metabolomics research.
Synthesis of findings to elucidate the role of molecular variations in CA.

Main Results:

Omics technologies reveal significant insights into the molecular underpinnings of CA.
Genetic variations, RNA transcripts, protein profiles, and metabolites are implicated in CA development and progression.
These advancements pave the way for identifying novel biomarkers and therapeutic strategies.

Conclusions:

Omics research is crucial for unraveling the complexities of CA.
Future directions include integrating multi-omics data for a holistic understanding of CA.
This approach holds promise for developing precision treatment strategies for cardiac arrest.