Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

40.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact Microindentation Evaluates Bone Strength, Bone Quality, and Fracture Susceptibility Across Skeletal Sites: A Cadaver Study.

Clinical orthopaedics and related research·2026
Same author

Crankshaft Phenomenon After Definitive Spinal Fusion in Pre-teens: Should We Be Concerned with Pedicle Screw Constructs?

Journal of the Pediatric Orthopaedic Society of North America·2026
Same author

Impact of GLP-1 Receptor Agonists on Chronic Low Back Pain in Patients with Obesity: A Prospective Pilot Cohort Study.

medRxiv : the preprint server for health sciences·2026
Same author

Genetic and pharmacologic modulation of RAGE rescues the diabetes-mediated impairments to bone at multiple length scales.

bioRxiv : the preprint server for biology·2026
Same author

Influence of subchondral bone density on intra-articular stresses due to fixation hardware instrumentation and removal: A biomechanical cadaver study.

Injury·2026
Same author

Sacral U-Type Fractures: A Comparative Study of Treatment Approaches.

Global spine journal·2026

Related Experiment Video

Updated: Jan 8, 2026

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
11:51

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

15.9K

Objective selection of bone mimetic materials using impact microindentation.

Lucas R Budd1,2, Rachana S Vaidya1, Babak Jahani1

  • 1Department of Orthopaedic Surgery, Washington University School of Medicine in St. Louis, MO, 63110, USA.

Journal of Orthopaedics
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a new objective measure for bone material strength using impact microindentation. This method helps select appropriate bone mimetic materials for orthopedic research and surgical training.

Keywords:
Bone hardnessBone mimetic selectionImpact microindentationImplant testingSurgical training

More Related Videos

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research
07:29

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research

Published on: September 27, 2024

1.2K
In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint
07:09

In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint

Published on: March 7, 2014

13.8K

Related Experiment Videos

Last Updated: Jan 8, 2026

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
11:51

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

15.9K
Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research
07:29

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research

Published on: September 27, 2024

1.2K
In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint
07:09

In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint

Published on: March 7, 2014

13.8K

Area of Science:

  • Orthopedic research
  • Biomaterials science
  • Medical device development

Background:

  • Orthopedic research requires bone mimetic materials that match physiologic conditions.
  • A need exists for objective material strength measurement in both synthetic and human bone.
  • Current methods lack practicality for in situ, non-destructive assessment.

Purpose of the Study:

  • To stratify synthetic bone mimetic materials and animal/human bone by material strength.
  • To establish a unified scale for comparing bone and mimetic material properties.
  • To simplify the selection of bone mimetics for orthopedic applications.

Main Methods:

  • Impact microindentation using the OsteoProbe device.
  • Quantification of the Bone Material Strength (BMS) index.
  • Classification of materials into Low, Mid, and High strength categories based on human tibia BMS ranges.

Main Results:

  • Nine mimetic materials classified as Low, two as Mid, and two as High.
  • Human male bone: cranium, radius, femur (High); spine (Mid).
  • Human female bone: spine (Low); radius (Mid); femur (High). Animal bone varied by species and location.

Conclusions:

  • A unified scale for bone and mimetic material strength was established.
  • Stratification into Low, Mid, and High categories simplifies material selection.
  • This framework aids targeted material selection in orthopedic research and surgical training.