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Infertility in Females01:28

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
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The process of hypothesis testing based on the traditional method includes calculating the critical value, testing the value of the test statistic using the sample data, and interpreting these values.
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Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
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Presenting a conceptual model for decision support systems in infertility: A developmental study.

Hasan Sajjadi1, Hamid Choobineh2,3, Reza Safdari1

  • 1Department of Health Information Management and Medical Informatics, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.

International Journal of Reproductive Biomedicine
|December 24, 2025
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Summary

This study developed a conceptual model for infertility decision support systems. The model, based on expert input and data analysis, aims to improve diagnosis and treatment accuracy for infertility patients.

Keywords:
Artificial intelligence.InfertilityIntelligent systemsExpert systems

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Area of Science:

  • Reproductive Medicine
  • Medical Informatics
  • Health Systems Engineering

Background:

  • Infertility affects individuals trying to conceive for over a year, leading to unintentional childlessness.
  • Clinical decision-support systems (CDSS) offer potential to improve infertility diagnosis, reduce costs, and enhance treatment accuracy.

Purpose of the Study:

  • To present a conceptual model for developing decision support systems specifically for infertility care.
  • To integrate data from literature, existing systems, and expert opinions into a cohesive model.

Main Methods:

  • A three-step developmental study involving literature review (PubMed, Scopus, Web of Science), identification of existing systems (Google, Yahoo, Bing, AI tools), and expert surveys (32 specialists).
  • Expert opinions were gathered using a researcher-designed questionnaire, with reliability (Cronbach's alpha=0.78) and validity (CVR=0.60) established.
  • Data analysis included systematic literature searches, competitor analysis of similar systems, and statistical analysis of expert consensus.

Main Results:

  • Literature and system searches identified 10 and 13 relevant systems, respectively.
  • Expert consensus reached high agreement (82.5%-94%) on key data requirements for infertility management, including monitoring, sperm analysis, and abortion data.
  • The conceptual model, encompassing main features, patient information management, fertility prediction, and secondary features, achieved 85% overall expert agreement.

Conclusions:

  • A decision support system for infertility holds promise for advancing clinical care and patient outcomes.
  • Key challenges for implementation include standardizing validation methodologies and ensuring consideration of ethnic diversity in system design.