Sulforaphane-cysteine elicits apoptosis through JNK-mediated caspase activation in oral squamous cell carcinoma cells

Yen-Lin Chen1,2, Yi-Tzu Chen1,2, Wei-En Yang3,4

  • 1School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.

Journal of Cancer
|December 24, 2025
PubMed

Insights

Sulforaphane-cysteine (SFN-Cys), a plant-derived compound, effectively combats oral squamous cell carcinoma (OSCC) by inducing cell death and halting progression. It activates apoptosis through the JNK pathway, offering a natural approach for oral cancer management.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Sulforaphane-cysteine (SFN-Cys) is a natural isothiocyanate metabolite with known tumor-suppressive properties.
  • The specific effects of SFN-Cys on oral squamous cell carcinoma (OSCC) remain largely uncharacterized.

Purpose of the Study:

  • To investigate the impact of SFN-Cys on OSCC progression.
  • To elucidate the molecular mechanisms underlying SFN-Cys's effects in OSCC cells.

Main Methods:

  • Treatment of OSCC cells with SFN-Cys.
  • Analysis of cell cycle progression, apoptosis induction, and protein regulation.
  • Assessment of caspase activation and the role of the c-Jun N-terminal kinase (JNK) pathway using specific inhibitors.

Main Results:

  • SFN-Cys demonstrated significant cytotoxicity against OSCC cells.
  • SFN-Cys induced cell cycle arrest and promoted apoptosis by downregulating apoptosis suppressors (cIAP-1, XIAP) and activating caspase cascades.
  • JNK pathway inhibition affected SFN-Cys-induced caspase activation, indicating its crucial role.

Conclusions:

  • SFN-Cys inhibits OSCC cell cycle progression and triggers apoptosis via JNK-mediated activation of caspase pathways.
  • These findings suggest SFN-Cys as a potential therapeutic agent for oral malignancies.

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