Neuroendocrine transformation of prostate adenocarcinoma with gallbladder metastases: Unusual case

Gallbladder metastasis from prostate cancer is exceptionally rare. We report the case of a 66-year-old man initially treated for high-risk prostatic adenocarcinoma with a combination of external beam radiotherapy and 2 years of androgen deprivation therapy. Six months after discontinuation of hormonal treatment, the patient developed bone and gallbladder metastases. Histopathological examination of the cholecystectomy specimen confirmed gallbladder involvement secondary to neuroendocrine transformation of the primary prostate cancer. To our knowledge, this is the first North African case of gallbladder metastasis arising from a neuroendocrine-transformed prostatic adenocarcinoma. We describe the clinical presentation and provide a brief literature review.