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Published on: January 16, 2013
Pulmonary Hypertension Associated With Sickle Cell Disease and Schistosomiasis
Claudia Mickael1,2, Jane C Kabwe3,4, Dara Fonseca Balladares5,6
1Cardiovascular Pulmonary Laboratory University of Colorado Anschutz Medical Campus Aurora Colorado USA.
None:
Schistosomiasis and sickle cell disease (SCD) both cause pulmonary hypertension (PH). We identified a subject with sickle cell trait and hepatosplenic schistosomiasis, who on right heart catheterization had PH, but due to high cardiac output. In a pre-clinical model, we found SCD mice were protected from developing schistosomiasis-induced PH.
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