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Association between ESRα and ESRβ polymorphisms and prostate cancer risk: meta-analysis
Xiaohui Bai1,2, Li Gao1,2, Jiawei Zhao1,2
1Department of Urology, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.
Frontiers in Oncology
|December 24, 2025
Summary
This study explored estrogen receptor gene (ESR) polymorphisms and prostate cancer risk. While ESRα PvuII and ESRβ RsaI showed potential associations, robust evidence was lacking, highlighting the need for further research.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Investigated associations between ESRα PvuII (rs2234693), ESRα XbaI (rs9340799), ESRβ AluI (rs4986938), and ESRβ RsaI (rs1256049) polymorphisms and prostate cancer risk.
- Previous studies yielded ambiguous results regarding these gene-cancer relationships.
- This research aimed to clarify the link between ESR gene variations and prostate cancer susceptibility.
Purpose of the Study:
- To examine the association between specific ESRα and ESRβ gene polymorphisms and the risk of developing prostate cancer.
- To evaluate the influence of ESRα PvuII, ESRα XbaI, ESRβ AluI, and ESRβ RsaI variants on prostate cancer incidence across different ethnicities.
- To assess the credibility of observed associations using rigorous statistical methods.
Main Methods:
- Systematic literature search of PubMed, Medline, and CNKI databases.
- Meta-analysis of case-control studies using odds ratios (ORs) and 95% confidence intervals (CIs).
- Credibility assessment of findings using false-positive report probability (FPRP), Bayesian false discovery probability (BFDP), and Venetian criteria.
Main Results:
- The ESRα PvuII polymorphism was associated with reduced prostate cancer risk overall and in Caucasians, but increased risk in Africans.
- The ESRβ RsaI polymorphism showed a reduced risk association in Asians.
- No significant associations were found for ESRα XbaI or ESRβ AluI polymorphisms; credibility assessments did not confirm robust relationships.
Conclusions:
- Suggests a potential role for ESRα PvuII and ESRβ RsaI polymorphisms in modulating prostate cancer risk.
- Emphasizes that current evidence lacks statistical robustness, necessitating further validation.
- Highlights ethnic variations in the association between ESR gene polymorphisms and prostate cancer.
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