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Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
Published on: June 14, 2020
Basic Science and Pathogenesis
Ezequiel Ignacio Surace1, Leonardo Romorini2, Mariela Marazita2
1Institute of Neurosciences (INEU), Fleni-CONICET, Buenos Aires, Buenos Aires, Argentina.
Abstract:
Understanding the biological and genetic landscape of neurodegenerative diseases in diverse populations deepens our insight into complex pathophysiological mechanisms. Our laboratory, established 14 years ago in Buenos Aires, Argentina, serves as a regional hub for Latin America, focusing on familial and sporadic cases of Alzheimer's disease (AD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS). We were among the first in the region to incorporate cerebrospinal fluid AD biomarker analysis into clinical diagnostics. Our research includes genetic counseling, the study of novel genetic variants, and the development of patient-derived cell models using induced pluripotent stem cell technology. In this talk, we will discuss the challenges of staying at the forefront of technological advancements and underscore the importance of international collaboration in advancing both local and global knowledge.
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