Related Experiment Video
Updated: May 2, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.7K
Exploring the Bidirectional Association Between Migraine and Temporomandibular Disorders: A Systematic Review and
Marlon Ferreira Dias1, Amanda Costa Ferro1, Juliana Homem Padilha Spavieri1
1Department of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Journal of Oral Rehabilitation
|December 24, 2025
Summary
Migraine and temporomandibular disorders (TMD) are strongly linked. Patients with migraine are more likely to have TMD, and vice versa, indicating a significant bidirectional association.
Area of Science:
- Neurology
- Oral and Maxillofacial Surgery
- Pain Management
Background:
- Migraine and temporomandibular disorders (TMD) are highly prevalent comorbid conditions.
- Understanding the relationship between these conditions is crucial for effective patient management.
Purpose of the Study:
- To systematically review and meta-analyze the bidirectional association between migraine and TMD in adults.
Main Methods:
- Searched 5 major databases and 3 grey literature databases.
- Included observational cross-sectional studies using standardized diagnostic criteria for TMD (RDC/TMD or DC/TMD) and migraine (ICHD).
- Assessed risk of bias and certainty of evidence using Joanna Briggs Institute and GRADE tools.
Main Results:
- Included 17 studies for qualitative and 6 for quantitative analysis, with most studies having low to moderate risk of bias.
- Found a significant association: migraine patients were 6.08 times more likely to have TMD (95% CI: 4.80-7.68).
- TMD patients were 2.64 times more likely to have migraine (95% CI: 2.19-3.18), with high certainty of evidence.
Conclusions:
- Established a strong bidirectional association between migraine and TMD.
- Recommends systematic screening for both conditions to improve treatment outcomes.
