Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potassium-solubilizing bacteria from tropical forest soils enhance potassium and phosphorus uptake in maize.

Frontiers in microbiology·2026
Same author

MRI-based tumor signatures as prognostic biomarkers in oral tongue squamous cell carcinoma.

Frontiers in oncology·2026
Same author

Symbiont dominance and microbiome dysbiosis in wheat-aphid revealed through 16 S rRNA gene amplicon sequencing analysis.

World journal of microbiology & biotechnology·2026
Same author

Adults With Acid Sphingomyelinase Deficiency Have Sustained Improvements in Clinical Outcomes With up to 5 Years of Olipudase Alfa Enzyme Replacement Therapy: ASCEND Trial Final Results.

Journal of inherited metabolic disease·2026
Same author

Comparison of Clinical and Pathological T Staging in Gingivobuccal Complex Cancers-A Retrospective Analysis.

Indian journal of surgical oncology·2026
Same author

Functional Oral Intake Scale as a Marker of Postoperative Speech and Swallowing Outcomes in Tongue Cancer Patients.

Indian journal of surgical oncology·2026
Same journal

Patient-derived forebrain cortical organoids reveal biphasic tau-MAP6-microtubule axis dysfunction in tauopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Plasma-based neurobiological protein biomarkers as predictors of dementia progression: Insights from longitudinal aging study in India - Diagnostic assessment of dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Neuropathology-specific language features in primary progressive aphasia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Dementia blood biomarkers in the context of post-stroke cognitive outcomes: Systematic review and evidence synthesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

Basic Science and Pathogenesis.

Isha Verma1, Monica Kumar1, Kirpal Bains1

  • 1Nova Southeastern University, Clearwater, FL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Semaglutide (Ozempic) shows potential in treating Alzheimer's disease by improving insulin resistance and reducing neuroinflammation. Further research is needed to confirm its long-term efficacy and safety in AD patients.

More Related Videos

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Related Experiment Videos

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Pharmacology

Background:

  • Alzheimer's disease (AD) is a neurodegenerative disorder with limited therapeutic options.
  • Emerging evidence links insulin resistance (IR), common in type 2 diabetes, to AD pathology, including neuroinflammation and hallmark protein aggregations.
  • Current AD treatments offer only temporary symptom relief.

Purpose of the Study:

  • To synthesize current research on the effects of semaglutide, a GLP-1 receptor agonist, on insulin resistance and neurodegeneration in Alzheimer's disease.
  • To evaluate the potential of semaglutide as a dual-action therapeutic for metabolic dysfunction and cognitive decline in AD.

Main Methods:

  • A comprehensive literature search was performed on PubMed and Google Scholar (2012-2024) using keywords: "semaglutide," "Ozempic," "GLP-1 receptor agonist," "insulin resistance," and "Alzheimer's disease."
  • Inclusion criteria focused on peer-reviewed clinical trials, meta-analyses, and preclinical studies in English, examining semaglutide's impact on IR and AD.
  • Exclusion criteria removed studies not relevant to semaglutide's effects on AD, non-peer-reviewed articles, and non-human studies.

Main Results:

  • Semaglutide enhances insulin sensitivity, reduces inflammation, and improves glucose metabolism, potentially crossing the blood-brain barrier to impact neuronal insulin signaling.
  • Studies indicate semaglutide may reduce amyloid-β and tau pathology, decrease neuroinflammation, and improve cognitive function.
  • Early clinical trials (e.g., ELAD) and observational studies suggest GLP-1 receptor agonists may lower AD risk and improve outcomes, with ongoing trials (e.g., EVOKE) investigating efficacy in early AD.

Conclusions:

  • Semaglutide demonstrates promising preclinical and early clinical results for Alzheimer's disease, particularly in addressing IR-related neurodegeneration.
  • Further investigation is required to determine long-term safety, optimal dosing, and definitive impact on AD progression.
  • Semaglutide holds potential as a dual-purpose therapeutic agent for both metabolic disorders and neurodegenerative conditions like AD.