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Targeting angiogenesis in cancer therapy: lessons learned and paths forward
1Barts Cancer Institute, Queen Mary University of London, London, UK.
Expert Review of Anticancer Therapy
|December 24, 2025
Summary
Anti-angiogenic therapies, which inhibit new blood vessel formation, are crucial in cancer treatment. Future research should focus on personalized medicine and combination strategies to improve efficacy and overcome resistance.
Area of Science:
- Oncology
- Vascular Biology
Background:
- Angiogenesis, the formation of new blood vessels, is vital for tumor growth and metastasis.
- Inhibiting angiogenesis is a key strategy in modern anticancer therapy.
Purpose of the Study:
- To review the biological processes of angiogenesis.
- To explore the clinical development and outcomes of anti-angiogenic therapies in various cancers.
Main Methods:
- Comprehensive literature search on approved and emerging anti-angiogenic agents.
- Analysis of combination strategies, clinical outcomes, limitations, and recent advances.
Main Results:
- Anti-angiogenic therapies have shown significant impact but face challenges like variable efficacy, drug resistance, and toxicity.
- Recent advances include biomarker discovery, immunotherapy combinations, and novel targets.
Conclusions:
- Anti-angiogenic agents have transformed cancer therapy but require further optimization.
- Future directions emphasize personalized medicine with predictive biomarkers and rational combination therapies to enhance efficacy and combat resistance.
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