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PknG Protein of Mycobacterium tuberculosis Targets RGDI-1 to Regulate Rab7l1 GTPase Activity

Rohini Shrivastava1,2, Rajesh Kotcherlakota1, Rituparna Chatterjee1,3

  • 1Laboratory of Molecular Cell Biology, BRIC-Centre for DNA Fingerprinting and Diagnostics, Inner Ring Road, Uppal, Hyderabad, Telangana 500039, India.

ACS Infectious Diseases
|December 24, 2025
PubMed
Summary

Mycobacterium tuberculosis PknG protein disrupts phagosome-lysosome fusion by inhibiting Rab7l1 GTPase activity via RGDI-1. Blocking this interaction reduces bacterial survival within host cells.

Keywords:
GTPase activityP-L fusionPknG proteinRGDI-1Rab7l1THP-1

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