Maternal Perinatal Depressive Symptoms, Prenatal Maternal Selective Serotonin Reuptake Inhibitor Antidepressants, and Executive Functions in Children: A 12-Year Longitudinal Study
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View abstract on PubMed
Summary
This summary is machine-generated.Maternal depression during pregnancy, not SSRI exposure, impacts child executive functions (EFs) long-term. Addressing maternal mental health is crucial for children's development.
Area Of Science
- Neuroscience
- Developmental Psychology
- Psychiatry
Background
- Maternal mental health during pregnancy is critical for offspring neurodevelopment.
- Selective serotonin reuptake inhibitor (SSRI) exposure in utero is a concern for developmental outcomes.
- Executive functions (EFs) are vital cognitive skills for academic and social success.
Purpose Of The Study
- To investigate the association between maternal depressive symptoms and prenatal SSRI exposure with offspring executive functions (EFs) at ages 6 and 12.
- To differentiate the impact of maternal depression versus SSRI treatment on child cognitive development.
Main Methods
- Prospective cohort study of 191 mother-child pairs.
- Longitudinal assessment of maternal depressive symptoms from pregnancy to 12 years postpartum.
- Measurement of offspring EFs using computer-based tasks and parent-report questionnaires (BRIEF) at ages 6 and 12.
Main Results
- Children demonstrated improved performance on EF tasks with age.
- Fewer maternal prenatal depressive symptoms correlated with better child accuracy on specific EF tasks and overall EF skills.
- Prenatal SSRI exposure was associated with more executive dysfunction at age 12, but this effect diminished when maternal depressive symptoms were controlled.
Conclusions
- Maternal depressive symptoms, both prenatal and later, appear to be a significant factor influencing offspring executive functions into preadolescence.
- Prenatal SSRI exposure's impact on EFs is likely confounded by maternal depressive symptoms.
- Long-term maternal mental health support is essential for optimizing children's executive function development and overall life success.
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