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Dimerization-activated PP2C-D2 and D5 phosphatases negatively regulate brassinosteroid signaling by antagonizing

Mengzhan Li1,2, Chunli Liu1, Shelley R Hepworth3

  • 1State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou 730020, China.

Proceedings of the National Academy of Sciences of the United States of America
|December 24, 2025
PubMed
Summary

D-clade type 2C protein phosphatases (PP2C-Ds) regulate plant growth by dephosphorylating the brassinosteroid (BR) receptor BRI1. Their activity is controlled by dimerization, which is disrupted by BR signaling, revealing a new regulatory mechanism.

Keywords:
BRI1PP2C-DsSAUR15dimerizationphosphorylation

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