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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Raina Vin1, Hae Young H Yi2, Sophia Moret1

  • 1Yale University School of Medicine, New Haven, CT, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Abnormal visual perception and reduced brain connectivity in Dementia with Lewy Bodies (DLB) may help identify REM sleep behavior disorder (RBD) patients at risk for DLB. This research offers insights for earlier diagnosis and treatment.

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Area of Science:

  • Neuroscience
  • Neurology
  • Psychiatry

Background:

  • Dementia with Lewy Bodies (DLB) and Parkinson's Disease (PD) involve α-synuclein aggregates and are often preceded by REM sleep behavior disorder (RBD).
  • DLB is characterized by early perceptual abnormalities and visual hallucinations, unlike PD.
  • Predictive markers for RBD conversion to DLB/PD are needed for early diagnosis and intervention.

Purpose of the Study:

  • To investigate neural mechanisms of perceptual abnormalities in DLB and prodromal RBD.
  • To identify potential biomarkers for distinguishing DLB/PD subtypes within RBD patients.

Main Methods:

  • Acquired structural and functional MRI data during movie viewing from 18 participants (RBD, DLB, PD).
  • Computed seed-based functional connectivity from the left lateral occipital cortex.
  • Administered the Noise Pareidolia Test and Multi-Modality Unusual Sensory Experiences Questionnaire (MUSEQ).

Main Results:

  • DLB participants showed higher MUSEQ scores and more illusory responses than PD participants.
  • RBD participants exhibited intermediate scores, suggesting distinct subgroups.
  • Increased illusory responses correlated with reduced connectivity in the ventral visual stream.

Conclusions:

  • Abnormal perception and visuospatial task performance may identify subgroups within prodromal RBD.
  • Reduced visual connectivity linked to illusory percepts offers insight into DLB's perceptual abnormalities.
  • Findings suggest potential for early detection and novel treatment strategies for DLB and prodromal RBD.