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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Julie Behenska1,2, Claire Elise Berner1, Elena Karpinski1

  • 1Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS AP-HP, Hôpital de la Pitié Salpêtrière, Paris, Ile de France, France.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

This study explores digital biomarkers to track apathy and anhedonia in dementia patients at home. These markers can help monitor symptoms and guide interventions, improving quality of life for individuals with dementia.

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Area of Science:

  • Neurology
  • Gerontology
  • Digital Health

Background:

  • Behavioural and Psychological Symptoms in Dementia (BPSD) monitoring lacks reliable home-based methods.
  • Apathy and anhedonia are key BPSDs in Alzheimer's disease (AD) and frontotemporal dementia (bvFTD), impacting quality of life.
  • Objective markers are needed for disease monitoring and targeted interventions.

Purpose of the Study:

  • To explore the utility of digital markers for capturing apathy and anhedonia in dementia patients within a home setting.
  • To extend the ECOCAPTURE@HOME framework to include digital assessment of apathy and anhedonia.
  • To identify reliable digital biomarkers for these BPSDs.

Main Methods:

  • The ECOCAPTURE@HOME study (NCT04865172) uses wearable sensors (Empatica EmbracePlus) and digital assessments.
  • Recruited 20 AD, 20 bvFTD patient-caregiver dyads, and 20 healthy controls across two sites.
  • Employed machine learning to analyze physiological and behavioral data for apathy and anhedonia profiles.

Main Results:

  • Hypothesizes that digital biomarkers can reliably identify and track apathy and anhedonia.
  • Apathy markers are expected to fluctuate with context, while anhedonia markers remain stable.
  • Digital markers will provide objective insights into these BPSDs.

Conclusions:

  • Novel objective behavioral indices for BPSDs will be developed for home implementation.
  • Digital biomarkers will facilitate timely interventions and therapeutic monitoring.
  • This approach supports patient autonomy, reduces caregiver stress, and enables aging in place.