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Association Between Complete Blood Count and the Lipoxygenase Pathway in Hashimoto's Thyroiditis

Karolina Wrońska1, Maciej Ziętek2, Tomasz Machałowski3

  • 1Department of Bromatology and Nutritional Diagnostics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.

Cells
|December 24, 2025
PubMed

Insights

Lipid mediators like eicosanoids may influence Hashimoto's Thyroiditis (HT) by affecting complete blood count (CBC) parameters. This research highlights potential new diagnostic markers and treatments for HT.

Area of Science:

  • Immunology
  • Endocrinology
  • Hematology

Background:

  • Hashimoto's Thyroiditis (HT) is a prevalent autoimmune disease with unclear pathogenesis.
  • The role of lipid mediators, specifically arachidonic acid (AA) derivatives, in HT is largely unknown.

Purpose of the Study:

  • To investigate the association between complete blood count (CBC) and lipoxygenase (LOX)-derived AA metabolites in female patients with HT.
  • To explore potential correlations between specific eicosanoids and hematological parameters in HT.

Main Methods:

  • Analysis of blood samples from 39 female patients diagnosed with HT.
  • Utilized liquid chromatography for the precise quantification of lipid mediators.

Main Results:

  • Observed neutropenia, lymphopenia, and basopenia in the study cohort.
  • Noted increased mean corpuscular volume (MCV) and decreased hematocrit (HCT) and hemoglobin (HGB) levels.
  • Found elevated levels of hydroxyeicosatetraenoic acids (5S-HETE, 12S-HETE, 15S-HETE) and 5-oxo-eicosatetraenoic acid (5-oxo-ETE).
  • Established strong positive correlations between these eicosanoids and C-reactive protein (CRP), neutrophils (NEUT), and eosinophils (EOS).
  • Identified significant correlations between eicosanoids and anthropometric measurements.

Conclusions:

  • Eicosanoids likely play a significant role in HT pathogenesis, impacting CBC.
  • Findings suggest eicosanoids could serve as novel diagnostic biomarkers for HT.
  • Further research may pave the way for new therapeutic strategies, potentially including anticancer treatments for the thyroid gland.
Abstract

Keywords:
AAHETEHashimoto’s ThyroiditisLOXLTLX blood countinflammation

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