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Plant-Derived Antioxidants as Modulators of Redox Signaling and Epigenetic Reprogramming in Cancer.

Thi Thuy Truong¹, Alka Ashok Singh², Soonhyuk Tak¹

¹Industry 4.0 Convergence Bionics Engineering, Department of Biomedical Engineering, Pukyong National University, Busan 48513, Republic of Korea.

|December 24, 2025

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Plant-derived antioxidants combat cancer by regulating reactive oxygen species (ROS) and reversing epigenetic changes. These natural compounds show promise as adjuncts in precision oncology, enhancing cancer therapies.

Area of Science:

Oncology
Epigenetics
Natural Product Chemistry

Background:

Cancer progression involves redox imbalance and epigenetic dysregulation.
Reactive oxygen species (ROS) play dual roles in cancer, promoting growth at moderate levels and apoptosis at high levels.
Oxidative stress impacts histone modifications, DNA methylation, and non-coding RNA expression, supporting malignant phenotypes.

Purpose of the Study:

To review the dual role of plant-derived antioxidants in cancer biology.
To explore their mechanisms in modulating redox balance and epigenetic landscape.
To discuss their potential as adjuncts in precision oncology.

Main Methods:

Literature review of studies on plant-derived antioxidants and cancer.
Analysis of mechanisms involving ROS scavenging, redox balance restoration, and epigenetic modulation.

Keywords:

ROS modulation cancer therapy epigenetic reprogramming plant-derived antioxidants redox signaling

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Examination of specific compounds like resveratrol, curcumin, EGCG, quercetin, and sulforaphane.

Main Results:

Plant antioxidants act as dual modulators, scavenging ROS, restoring redox balance, and reversing epigenetic alterations.
Compounds like resveratrol and EGCG modulate DNA methyltransferases (DNMTs), histone deacetylases (HDACs), and non-coding RNA networks.
These antioxidants can enhance the efficacy of chemotherapy and radiation therapy.

Conclusions:

Plant-derived antioxidants hold significant potential as precision oncology adjuncts.
Challenges in translational efficacy, dosing, and bioavailability require further research.
Biomarker-guided strategies and nano-delivery systems are crucial for clinical translation.