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Related Concept Videos

Erythropoiesis01:14

Erythropoiesis

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Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
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Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

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The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
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Disorders of Erythrocytes01:27

Disorders of Erythrocytes

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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
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Translation01:31

Translation

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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
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Translation01:31

Translation

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Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
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Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
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Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
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The Non-Coding RNome Landscape in Erythropoiesis: Pathophysiological Implications.

Emma Brisot1, Laurent Metzinger1, Valérie Metzinger-Le Meuth1,2

  • 1HEMATIM UR-UPJV 4666, C.U.R.S, University of Picardie Jules Verne, CEDEX 1, 80025 Amiens, France.

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Non-coding RNAs (ncRNAs) are key regulators of red blood cell production (erythropoiesis). This review details how microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) influence erythroid differentiation and function, offering potential therapeutic targets.

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biomarkererythropoiesisgene regulationlong non-coding RNAmicroRNAred blood cell

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Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay
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Mouse Fetal Liver Culture System to Dissect Target Gene Functions at the Early and Late Stages of Terminal Erythropoiesis
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Area of Science:

  • Hematology
  • Molecular Biology
  • Genetics

Background:

  • Erythropoiesis, the process of red blood cell production, is crucial for oxygen transport.
  • Non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are increasingly recognized for their regulatory roles in biological processes.
  • Dysregulation of erythropoiesis is associated with various hematologic disorders, such as anemia.

Purpose of the Study:

  • To review the multifaceted roles of ncRNAs in regulating erythroid differentiation, maturation, and function.
  • To explore the mechanisms by which miRNAs and lncRNAs fine-tune erythropoiesis at transcriptional and post-transcriptional levels.
  • To highlight the potential of ncRNAs as biomarkers and therapeutic targets for hematologic disorders.

Main Methods:

  • Literature review and synthesis of existing research on ncRNAs in erythropoiesis.
  • Analysis of studies investigating the impact of specific miRNAs and lncRNAs on erythroid lineage commitment, hemoglobin synthesis, iron metabolism, and cellular morphology.
  • Examination of evidence linking ncRNAs to chromatin remodeling, splicing, apoptosis, and enucleation during erythropoiesis.

Main Results:

  • Specific miRNAs significantly influence erythroid lineage commitment, hemoglobin switching, iron metabolism, and cell morphology.
  • lncRNAs play critical roles in regulating chromatin structure, alternative splicing, apoptosis, enucleation, and erythroid gene expression.
  • ncRNAs are modulated by environmental factors and pathological conditions, impacting erythropoiesis.

Conclusions:

  • ncRNAs are essential orchestrators of physiological and pathological erythropoiesis.
  • Understanding the ncRNA landscape provides insights into the complex regulation of red blood cell production.
  • ncRNAs represent promising biomarkers and therapeutic targets for anemias and related hematologic conditions.