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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Tarin T Tanji1, Michael Anukwu2, Jianing Tang3

  • 1Rush University Medical College, Chicago, IL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Aging reduces lenticulostriate arteries (LSAs) number and length, impacting cognitive function and vascular health. This study highlights age-related LSA changes linked to hypertension and high cholesterol.

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Area of Science:

  • Neuroimaging
  • Vascular Biology
  • Gerontology

Background:

  • Lenticulostriate arteries (LSAs) are crucial perforating vessels of the middle cerebral artery (MCA).
  • LSAs play a significant role in cerebral small vessel disease and cognitive function.
  • Age-related changes in LSA morphology are not well understood.

Purpose of the Study:

  • To investigate age-related morphological alterations in LSAs.
  • To analyze the association between LSA geometry, cognitive function, and vascular risk factors.

Main Methods:

  • Utilized 7T high-resolution Time-Of-Flight (TOF) Magnetic Resonance Angiography in 29 participants (8 young, 21 older).
  • LSAs were manually segmented; stems and branches were analyzed for length and number.
  • Statistical analyses included t-tests and linear mixed-effect models.

Main Results:

  • Older adults exhibited significantly fewer LSA stems and branches compared to younger adults.
  • LSA length was shorter in older individuals, though not statistically significant.
  • In older adults, LSA geometry correlated with blood pressure, cholesterol levels, and cognitive function scores (MMSE, MoCA).

Conclusions:

  • Age-related deterioration of LSA geometry was confirmed.
  • Changes in LSA morphology are closely linked to cognitive decline.
  • Vascular risk factors like hypertension and hyperlipidemia are associated with altered LSA geometry in aging.