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Accuracy of Surgical Guides in Guided Apical Surgery: An In Vitro Comparative Study
Nancy Soraya Romero Mora1, Maria Soledad Peñaherrera Manosalvas1, Henry Paul Valverde Haro1,2
1Postgraduate Program in Dentistry, Universidad de los Hemisferios, Quito 170527, Ecuador.
Dentistry Journal
|December 24, 2025
Summary
Exoplan software offers superior accuracy, stability, and efficiency for guided endodontic microsurgery trephinations compared to Blue Sky Plan and freehand methods. This digital guide technology enhances safety and predictability in endodontic procedures.
Area of Science:
- Dentistry
- Surgical Technology
- Endodontics
Background:
- Guided endodontic microsurgery offers improved safety and precision over freehand techniques.
- Stereolithographic surgical guides are increasingly used in dental procedures.
- Digital planning software aids in creating precise surgical guides.
Purpose of the Study:
- To evaluate the accuracy, stability, and operative time of trephinations using stereolithographic surgical guides.
- Compare Exoplan and Blue Sky Plan software against the conventional freehand technique.
- Assess the clinical potential of digital guides in endodontic microsurgery.
Main Methods:
- Comparative in vitro study on 72 roots from 12 mandibles.
- Superimposition of cone-beam computed tomography (CBCT) and intraoral scans for guide design.
- Trephinations performed using freehand, Blue Sky Plan, and Exoplan guided techniques.
Main Results:
- Exoplan showed superior accuracy with 0.17 mm deviation.
- Exoplan demonstrated significantly better stability with 12.5% failures compared to 50% for Blue Sky Plan.
- Exoplan achieved the shortest operative time (106 s) versus Blue Sky Plan (127 s) and freehand (155 s).
Conclusions:
- Exoplan-guided trephinations outperformed Blue Sky Plan and freehand techniques in stability, accuracy, and efficiency.
- Digital guides show promise for enhancing safety and predictability in endodontic microsurgery.
- Further clinical validation is necessary to confirm these findings in practice.

