Related Experiment Video
Updated: Jan 7, 2026

Establishing a Competing Risk Regression Nomogram Model for Survival Data
Published on: October 23, 2020
Epidemiological and Clinical Behavior of Snakebite in the Pediatric Population, Associated with a Logistic Regression
Cándida Revollo Vargas1, Osnamir Bru-Cordero2, Karina Pastor-Sierra3
1Especialista en Pediatría, Facultad de Ciencias de la Salud, Universidad del Sinú E.B.Z., Montería 230001, Colombia.
Insights
Snakebite envenomation in children is a significant public health issue. Non-medical practices, like herbal remedies, increase the risk of severe envenomation and complications in pediatric patients.
Area of Science:
- Tropical Medicine
- Pediatric Toxicology
- Epidemiology
Background:
- Snakebite envenomation is a neglected tropical disease with significant impact, particularly on children in Colombia.
- High diversity of ecosystems and snake species contribute to frequent snakebite incidents.
- Pediatric populations are especially vulnerable to snakebite envenomation outcomes.
Purpose of the Study:
- To characterize the epidemiology and clinical presentation of snakebite envenomation in pediatric patients.
- To identify factors associated with envenomation severity using multinomial logistic regression.
- To assess the impact of non-medical practices on snakebite severity in children.
Main Methods:
- Exploratory analysis of 170 pediatric cases from the Public Health Surveillance System (SIVIGILA).
- Data collection included sociodemographic and clinical information from patients treated at San Jerónimo Hospital.
- Multinomial logistic regression applied to determine risk factors for envenomation severity.
Main Results:
- Most cases (51.8%) involved children over 12; males were predominantly affected.
- Lower limbs were the most common bite site (87.6%), with *Bothrops* as the primary snake genus.
- Non-medical practices (herbal poultices/potions) reported in 28.2%; associated with increased severe cases.
- Moderate envenomation was most frequent (48.2%); common manifestations included edema and pain; cellulitis was the main complication.
- Multinomial logistic regression explained 75% of severity variability, highlighting non-medical practices as a significant risk factor.
Conclusions:
- Pediatric snakebite envenomation remains a critical public health concern in Colombia.
- Non-medical practices are statistically associated with a higher degree of envenomation severity in children.
- Effective public health strategies should address and discourage harmful non-medical interventions.
Abstract:
Introduction: Snakebite envenomation is recognized by the World Health Organization (WHO) as a neglected tropical disease. In Colombia, snakebites are frequent due to the diversity of ecosystems and snake species, and children represent a particularly vulnerable population. Objective: This study aimed to characterize the epidemiological and clinical behavior of snakebite envenomation in the pediatric population and to identify factors associated with its severity through the application of a multinomial logistic regression model. Methods: An exploratory analysis was conducted on 170 pediatric patients reported to the Public Health Surveillance System (SIVIGILA) and treated at San Jerónimo Hospital in Montería (HSJ). Sociodemographic and clinical data were collected, and a multinomial logistic regression model was applied to identify risk factors associated with the severity of envenomation. Results: Most cases occurred in children over 12 years of age (51.8%), and males were the most affected. The lower limbs were the most common site of the bite (87.6%). Bothrops was the main genus responsible. Non-medical practices, such as herbal poultices and potions, were reported in 28.2% of cases. Clinically, moderate envenomation was the most frequent (48.2%), with edema (88%) and pain (92%) as the main local manifestations, and nausea (36%) and vomiting (32%) as systemic manifestations. Cellulitis was the most common complication (24%). Student's t-test showed a significant difference between complications and hospital stays lasting 3 to 7 days. The multinomial logistic regression explained 75% of the severity variability and showed that prior non-medical practices increased the risk of severe cases. Conclusions: Snakebite envenomation in children remains an important public health problem. The statistical model showed that non-medical practices are associated with a higher degree of severity.
Related Concept Videos
Statistical Methods for Analyzing Epidemiological Data
Steps in Outbreak Investigation
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Mechanistic Models: Compartment Models in Individual and Population Analysis
Hazard Ratio
For example, in a clinical trial...
Statistical Software for Data Analysis and Clinical Trials

