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Related Experiment Video

Updated: Jul 6, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
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Obesogenic Dysregulation of Human Periprostatic Adipose Tissue Promotes the Viability of Prostate Cells and Reduces

Mariana Feijó1, Lara R S Fonseca1, Gonçalo Catarro2,3

  • 1RISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Rua Marquês d'Ávila e Bolama, 6201-001 Covilhã, Portugal.

Medical Sciences (Basel, Switzerland)
|December 24, 2025
PubMed
Summary

Obesogens disrupt prostate fat tissue, increasing prostate cancer (PCa) cell survival and reducing chemotherapy effectiveness. This highlights a new target for managing PCa progression and treatment resistance.

Keywords:
cabazitaxeldocetaxelendocrine-disrupting chemicalsobesogensperiprostatic adipose tissueprostate cancer

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Area of Science:

  • Endocrinology
  • Oncology
  • Environmental Health

Background:

  • Periprostatic adipose tissue (PPAT) influences prostate cancer (PCa) development and progression.
  • Obesity and obesogens exacerbate PCa aggressiveness and chemotherapy resistance via PPAT.
  • Understanding PPAT-prostate crosstalk is crucial for PCa management.

Purpose of the Study:

  • Investigate how obesogenic disruption of human PPAT affects PCa cell viability.
  • Assess the impact of obesogen-altered PPAT on PCa cell response to docetaxel and cabazitaxel.

Main Methods:

  • Ex vivo culture of human PPAT.
  • Conditioned medium assays using PPAT secretome.
  • Exposure to the model obesogen tributyltin (TBT).

Main Results:

  • TBT induced an "obese" phenotype in human PPAT.
  • TBT-treated PPAT showed enlarged adipocytes and increased leptin and CCL7 secretion.
  • The TBT-PPAT secretome boosted PCa cell viability and decreased taxane sensitivity.

Conclusions:

  • Obesogen-dysregulated PPAT may promote prostate carcinogenesis.
  • This dysregulation contributes to chemotherapy resistance in PCa.
  • Further research is needed to elucidate molecular pathways involved.