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Related Concept Videos

Hydration of Cement01:24

Hydration of Cement

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Hydration of cement is a chemical reaction between cement particles and water. This process occurs primarily through two mechanisms: through-solution and topochemical. In the through-solution process, anhydrous compounds dissolve into their constituents, hydrates form in the solution, and then precipitate from the supersaturated solution. The topochemical process involves solid-state reactions at the cement particle surface. The through-solution process dominates the topochemical process at the...
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Ionic Strength: Effects on Chemical Equilibria01:19

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The addition of an inert ionic compound increases the solubility of a sparingly soluble salt. For example, adding potassium nitrate to a saturated solution of calcium sulfate significantly enhances the solubility of calcium sulfate. Le Châtelier's principle cannot predict this shift in the equilibrium. Instead, this could be explained in terms of changes in the effective concentration of the ions in solution in the presence of added inert salt.
In this solution, the primary...
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Enhancing Radiopacity and Antibacterial Activity of Osteogenic Calcium Silicate Cement by Incorporating Strontium.

Ting-Yi Chiang1, Yu-Ci Lu2, Chun-Cheng Chen3,4

  • 1Department of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, Taichung 406, Taiwan.

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|December 24, 2025
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Summary

Strontium-modified calcium silicate cements show enhanced radiopacity and antibacterial properties for bone repair. CSSr10 demonstrates optimal balance for bone filler applications, improving cell activity and mineralization.

Keywords:
antibacterial activitybone cementcalcium silicateosteogenic activityradiopacifierstrontium

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Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Dental Materials

Background:

  • Calcium silicate-based cements are vital for bone regeneration and repair.
  • Radiopacity and antibacterial properties are crucial for clinical success in bone defect treatments.
  • Strontium (Sr) incorporation enhances osteogenesis and reduces bone resorption.

Purpose of the Study:

  • To investigate the effects of varying strontium (Sr) concentrations (5, 10, 20 mol%) on calcium silicate cement properties.
  • To assess radiopacity, setting time, bioactivity, antibacterial efficacy, and osteogenic activity.
  • To identify an optimal Sr-modified cement formulation for bone applications.

Main Methods:

  • Synthesized strontium-modified calcium silicate cements (CSSr5, CSSr10, CSSr20).
  • Evaluated radiopacity against ISO 6876:2001 standards.
  • Assessed setting time, in vitro bioactivity using MG63 cells, and antibacterial activity against E. coli and S. aureus.

Main Results:

  • Increased Sr content correlated with longer setting times and higher radiopacity.
  • CSSr10 and CSSr20 exceeded the 3 mm aluminum radiopacity standard.
  • Sr addition significantly enhanced MG63 cell proliferation, differentiation, and mineralization.
  • Antibacterial efficacy against E. coli and S. aureus increased with Sr concentration.

Conclusions:

  • Strontium-modified calcium silicate cements offer improved radiopacity and antibacterial properties.
  • CSSr10 exhibits a favorable balance of properties, making it a promising candidate for bone filler applications.
  • The study highlights the potential of Sr as a beneficial additive for bone regenerative biomaterials.