Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

10.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishment of epidemiological cutoff values against <i>Fonsecaea monophora</i>, an agent of chromoblastomycosis and cerebral phaeohyphomycosis.

Journal of clinical microbiology·2026
Same author

Reply to Chen et al., "Methodological considerations for the establishment of epidemiological cutoff values for <i>Sporothrix</i> species using CLSI broth microdilution".

Antimicrobial agents and chemotherapy·2026
Same author

Manogepix demonstrates potent <i>in vitro</i> activity against <i>Aspergillus, Coccidioides</i>, <i>Scopulariopsis/Microascus, Rasamsonia</i>, and <i>Purpureocillium</i> species, including strains with <i>in vitro</i> resistance to other antifungals.

Antimicrobial agents and chemotherapy·2026
Same author

Erratum for Wiederhold et al., "The next-generation polyene EL219 is efficacious in an experimental model of central nervous system coccidioidomycosis caused by <i>Coccidioides immitis</i>".

Antimicrobial agents and chemotherapy·2026
Same author

Myeloid-derived suppressor cell (MDSC)-like neutrophils induced by pulmonary infection with <i>Coccidioides posadasii</i> exacerbate disease by suppressing CD4<sup>+</sup> T cell immunity.

mBio·2026
Same author

<i>Candidozyma auris</i> and the Perfect Storm of Fungal Pathogenicity: Adaptation, Persistence, and Resistance.

Journal of fungi (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jan 7, 2026

A High-throughput, High-content, Liquid-based C. elegans Pathosystem
09:44

A High-throughput, High-content, Liquid-based C. elegans Pathosystem

Published on: July 1, 2018

15.1K

Drug Discovery and Repurposing for Coccidioides: A Systematic Review.

Sarah Saeger1, Sofia Lozano1, Nathan Wiederhold2

  • 1Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA.

Journal of Fungi (Basel, Switzerland)
|December 24, 2025
PubMed
Summary

Coccidioidomycosis (CM) treatment options are limited, often causing toxicity and resistance. This review explores new and repurposed antifungal compounds to combat Valley Fever effectively.

Keywords:
Coccidioidesamphotericin Bantifungal drugscoccidioidomycosisdrug resistancefluconazolevalley fever

More Related Videos

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

19.9K
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

10.1K

Related Experiment Videos

Last Updated: Jan 7, 2026

A High-throughput, High-content, Liquid-based C. elegans Pathosystem
09:44

A High-throughput, High-content, Liquid-based C. elegans Pathosystem

Published on: July 1, 2018

15.1K
Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

19.9K
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

10.1K

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Coccidioidomycosis (CM), or Valley Fever, is caused by *Coccidioides immitis* and *C. posadasii*.
  • Current treatments for CM primarily use triazoles and polyenes, with limited alternatives.
  • Existing therapies often require prolonged treatment, leading to toxicity and drug resistance.

Purpose of the Study:

  • To review novel and repurposed compounds for treating Coccidioidomycosis (CM).
  • To address the urgent need for improved antifungal drugs against CM due to limitations of current therapies.

Main Methods:

  • Literature review of repurposed and newly discovered compounds.
  • Examination of compounds in various developmental stages for CM treatment.

Main Results:

  • Identification of promising antifungal compounds beyond traditional drug classes.
  • Assessment of the developmental pipeline for novel CM therapeutics.

Conclusions:

  • There is a critical need for new antifungal agents to treat Coccidioidomycosis.
  • Repurposed and novel compounds show potential to overcome current treatment challenges, including toxicity and resistance.