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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Futao Chen1, Bing Zhang2, Qian Chen1

  • 1Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Glymphatic system dysfunction, measured by DTI-ALPS and CPV, is linked to spatial navigation deficits in early Alzheimer's Disease stages like subjective cognitive decline (SCD). This dysfunction may serve as an early diagnostic marker for AD.

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Area of Science:

  • Neuroscience
  • Radiology
  • Gerontology

Background:

  • Glymphatic system dysfunction is associated with cognitive decline in Alzheimer's Disease (AD), especially in early stages like subjective cognitive decline (SCD).
  • The relationship between glymphatic function and spatial navigation, an early AD symptom, remains unclear.
  • Ultra-high-field 5.0T MRI can assess glymphatic function and spatial navigation in SCD individuals.

Purpose of the Study:

  • To evaluate glymphatic function in SCD individuals using diffusion tensor image analysis of the perivascular space (DTI-ALPS) and choroid plexus volume (CPV) measurements.
  • To explore the relationship between glymphatic function and spatial navigation abilities in SCD.
  • To investigate the potential of glymphatic measures as early diagnostic markers for AD.

Main Methods:

  • 62 SCD patients and 62 controls underwent 5.0T MRI, spatial navigation tests, cognitive evaluations, and plasma biomarker analyses.
  • Glymphatic function was assessed using the ALPS index from DTI data and CPV from 3DT1WI.
  • Statistical analyses included MANOVA, partial correlation, multiple regression, and mediation analysis.

Main Results:

  • SCD patients showed significant spatial navigation deficits and glymphatic dysfunction (lower ALPS index, higher CPV) compared to controls.
  • Glymphatic measures (DTI-ALPS, CPV) were correlated with navigation errors and predicted navigation performance.
  • Mediation analysis indicated that the ALPS index mediates the relationship between CPV and spatial navigation deficits.

Conclusions:

  • Glymphatic dysfunction is correlated with impaired spatial navigation in early SCD.
  • These findings suggest glymphatic function as a potential physiological marker for early AD diagnosis.
  • Further research is warranted to validate these findings and explore therapeutic interventions targeting the glymphatic system.