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Related Experiment Video

Updated: Jan 7, 2026

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
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Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

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Development and Validation of an Acute Large Animal Model for Type A Aortic Dissection.

Ezin Deniz1, Sibylle Marsen1, Florian Helms1

  • 1Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany.

Journal of Cardiovascular Development and Disease
|December 24, 2025
PubMed
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Tissue engineering. Part A·2026

Researchers developed a new large animal model for acute Stanford type A aortic dissection. This swine model combines surgical and endovascular methods for reproducible preclinical studies.

Area of Science:

  • Cardiovascular Research
  • Surgical Innovation
  • Animal Models

Background:

  • Aortic dissection animal models are crucial for advancing clinical diagnostics and therapeutics.
  • Stanford type A aortic dissection presents significant clinical challenges.
  • Existing models may not fully replicate human pathophysiology.

Purpose of the Study:

  • To establish a novel, acute in vivo large animal model of Stanford type A aortic dissection.
  • To combine open surgical and endovascular techniques for a hybrid approach.
  • To create a reproducible platform for evaluating diagnostic and therapeutic strategies.

Main Methods:

  • A standardized protocol was applied to six pigs to induce aortic dissection.
  • A hybrid approach involving sternotomy and catheter-based techniques was employed.
Keywords:
aortic dissectionlarge animal modeltype A

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  • Animals were monitored for 12 hours post-intervention, followed by aortic analysis.

    • Main Results:

    • The dissection model was successfully created in 5 out of 6 animals.
    • Clinical signs such as adventitial hematoma and wall separation were observed.
    • The procedure was technically feasible with no immediate complications in most animals.

    Conclusions:

    • A standardized, reproducible, and robust large animal model for acute Stanford type A aortic dissection was developed.
    • The hybrid model accurately mimics human aortic dissection features.
    • This model serves as a valuable tool for preclinical research and treatment development.