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Structural Diversity and Bioactivities of Mangrove-Derived Fungal Polyketids (2020-2025)
Miao Yu1,2, Caijuan Zheng2, Guangjin Zheng1
1College of Chemical and Material, Guangxi Minzu Normal University, Chongzuo 532200, China.
Marine Drugs
|December 24, 2025
Summary
Mangrove fungi yield numerous unique compounds with significant medicinal potential. This review highlights 457 metabolites from mangrove-derived fungi, showcasing their value for drug discovery and development.
Area of Science:
- Marine biology
- Mycology
- Natural products chemistry
Background:
- Mangrove forests host diverse microbial communities, with fungi being crucial for ecosystem health.
- Mangrove-derived fungi are a rich source of unique secondary metabolites with potential biological activities.
Purpose of the Study:
- To systematically review metabolites isolated from mangrove-derived fungi and their bioactivities from 2020-2025.
- To highlight the chemical diversity and medicinal value of these compounds.
Main Methods:
- Comprehensive literature search of scientific publications from 2020-2025.
- Systematic summarization of 457 metabolites and their associated biological activities.
- Analysis of chemical diversity and potential lead compounds.
Main Results:
- 97 publications documented 457 distinct metabolites from mangrove-derived fungi.
- These metabolites exhibit a wide range of biological activities.
- Significant chemical diversity was observed among the secondary metabolites.
Conclusions:
- Mangrove-derived fungi represent a valuable resource for discovering novel bioactive compounds.
- Further research into these metabolites holds promise for pharmaceutical and medicinal applications.
- These fungi possess significant untapped medicinal value for future development.
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