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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Correction: Assalve et al. Marine Algal Metabolites as Cellular Antioxidants: A Study of Caulerpin and Caulerpinic Acid in <i>Saccharomyces cerevisiae</i>. <i>Mar. Drugs</i> 2025, <i>23</i>, 338.

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Related Experiment Video

Updated: May 6, 2026

Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections
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Precision-Engineered Dermatan Sulfate-Mimetic Glycopolymers for Multi-Targeted SARS-CoV-2 Inhibition.

Lihao Wang1, Lei Gao1, Chendong Yang1

  • 1Key Laboratory of Marine Drugs of Ministry of Education, Shandong Key Laboratory of Glycoscience and Glycotherapeutics, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Marine Drugs
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

New glycopolymers mimic dermatan sulfate to create multi-targeted inhibitors against SARS-CoV-2. These nanoparticles neutralize the virus by targeting the spike protein and key viral enzymes, offering a promising complementary strategy to vaccines.

Keywords:
anti-SARS-CoV-2dermatan sulfatedisaccharideglycopolymersynthesis

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Area of Science:

  • Biochemistry
  • Polymer Science
  • Virology

Background:

  • COVID-19 remains a global health threat due to SARS-CoV-2 variants, vaccine limitations, and waning immunity.
  • There is a critical need for novel antiviral therapeutics to complement existing vaccines and combat emerging strains.

Purpose of the Study:

  • To design and synthesize precision-engineered dermatan sulfate (DS)-mimetic glycopolymers as multi-targeted SARS-CoV-2 inhibitors.
  • To evaluate the efficacy of these glycopolymers in inhibiting viral entry and replication.

Main Methods:

  • Molecular docking and virtual screening identified key sulfation sites for targeting SARS-CoV-2.
  • Chemically synthesized DS disaccharides were grafted onto polymer scaffolds, forming nanoparticles.
  • Surface plasmon resonance, pseudovirus assays, and cellular uptake studies were employed for biological evaluation.

Main Results:

  • Glycopolymers demonstrated strong binding to the SARS-CoV-2 spike protein (KD ≈ 177 nM) and potent viral neutralization.
  • Nanoparticles effectively inhibited heparanase (HPSE) and main protease (Mpro) intracellularly with minimal cytotoxicity.
  • The developed platform is non-anticoagulant and mimics glycosaminoglycans.

Conclusions:

  • Precision-engineered DS-mimetic glycopolymers represent a novel class of broad-spectrum antiviral agents.
  • This modular platform offers a promising strategy to complement vaccination and enhance preparedness against SARS-CoV-2 variants.
  • The findings support the development of advanced antiviral therapeutics targeting multiple viral and host factors.