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Distinct Circulating Biomarker Profiles Associated with Type 2 Diabetes in a Regional Cohort-A Cross-Sectional Study
Abdullah Alsrhani1, Muhammad Atif1, Aisha Farhana1
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia.
Type 2 diabetes mellitus (T2DM) is rising in Saudi Arabia. Hyperuricemia and vitamin D deficiency are key predictors of T2DM in the Aljouf region, suggesting their importance for public health initiatives.
Area of Science:
- Endocrinology and Metabolism
- Biochemistry
- Public Health
Background:
- Type 2 diabetes mellitus (T2DM) prevalence has surged in Saudi Arabia, reaching 28% in 2023.
- The Aljouf region shows a significant increase in T2DM cases, necessitating regional studies.
Purpose of the Study:
- To identify and quantify biochemical factors associated with T2DM in the Aljouf region.
- To compare biomarkers between T2DM patients and healthy controls.
- To determine key risk factors for T2DM in the local population.
Main Methods:
- A cross-sectional study involving 114 T2DM patients and 91 healthy controls.
- Analysis of lipid profiles, vitamin B12 and D levels, liver function, and renal markers.
- Statistical analysis using t-tests, correlation, and logistic regression.
Main Results:
- T2DM patients exhibited elevated triglycerides, LDL cholesterol, and serum uric acid.
- Significant deficiencies in vitamin B12 and vitamin D were observed in T2DM patients.
- Hyperuricemia (OR=4.85) and vitamin D deficiency (OR=3.62) were independent predictors of T2DM.
Conclusions:
- Distinct biochemical profiles characterize T2DM patients in the Aljouf region.
- Hyperuricemia and vitamin D deficiency are strongly associated with T2DM in this population.
- These biomarkers can inform public health strategies and clinical interventions for T2DM in the region.
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