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Influence of Retinol Dermal Delivery Formulation on Its Stability Characteristics.
Ioana Lavinia Lixandru Matei1,2, Bogdan Alexandru Sava2,3, Codruta Sarosi4
1Botanical SRL, 7 Trandafirilor St., 107059 Tătărani, Romania.
Gels (Basel, Switzerland)
|December 24, 2025
Summary
New cosmeceutical formulas combining bioglass and retinol were developed to reduce retinoid irritation and enhance efficacy. These stable formulations, including emulsions and hydrogels, show promising characteristics for therapeutic use.
Area of Science:
- Cosmetic science
- Materials science
- Dermatology
Background:
- Retinoids are effective but can cause skin irritation.
- Bioglass offers potential therapeutic benefits.
- Combining these could create improved cosmeceuticals.
Purpose of the Study:
- To develop and characterize novel cosmeceutical formulations.
- To combine bioglass with retinol in direct emulsion, inverse emulsion, and hydrogel forms.
- To evaluate the synergistic effects on retinoid irritation and efficacy.
Main Methods:
- Preparation and characterization of direct emulsion, inverse emulsion, and hydrogel formulations.
- Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC) to assess interactions.
- Stability testing using backscattering variation and droplet analysis.
Main Results:
- TGA and DSC indicated stronger interactions between water and organic compounds in emulsions compared to hydrogels, delaying water evaporation.
- Formulations demonstrated high stability through backscattering and droplet analysis.
- The combination of bioglass and retinol showed potential for reduced irritation and prolonged efficacy.
Conclusions:
- Novel cosmeceutical formulations integrating bioglass and retinol were successfully developed.
- The formulations exhibited excellent physicochemical and microbiological stability.
- These findings suggest a promising approach to mitigate retinoid-induced irritation and enhance therapeutic outcomes.
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