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Multifunctional Metal Composite Hydrogels for Diabetic Wound Therapy
Shengnan Zhang1, Hui Gao1, Kevin H Mayo2
1College of Life Science, Changchun Normal University, Changchun 130032, China.
Gels (Basel, Switzerland)
|December 24, 2025
Summary
Metal composite hydrogels offer advanced diabetic wound healing by combining antibacterial and anti-inflammatory properties with moist wound environments. This review explores their design, mechanisms, and future clinical applications for improved patient outcomes.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Wound Healing Research
Background:
- Diabetic wounds present complex challenges including hyperglycemia, inflammation, and infection.
- Metal composite hydrogels offer a promising therapeutic platform for diabetic wound management.
Purpose of the Study:
- To review recent advancements in metal composite hydrogels for diabetic wound care.
- To detail their design strategies, mechanisms of action, and therapeutic potential.
Main Methods:
- Physical, chemical, and hybrid doping methods for material design.
- Analysis of multimodal action mechanisms: antibacterial, anti-inflammatory, antioxidant.
- Assessment of tissue repair promotion: angiogenesis, collagen remodeling.
Main Results:
- Metal composite hydrogels exhibit potent antibacterial, anti-inflammatory, and antioxidant activities.
- Mechanisms include ROS generation, photothermal therapy, and immunomodulation.
- These materials promote angiogenesis and collagen remodeling for enhanced tissue repair.
Conclusions:
- Metal composite hydrogels show significant potential for treating diabetic wounds.
- Further research is needed on biosafety, scalable fabrication, and clinical translation.
