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Senotherapeutics for Brain Aging Management.

Timur Saliev1,2, Prim B Singh1

  • 1School of Medicine, Nazarbayev University, Astana 010000, Kazakhstan.

Neurology International
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Cellular senescence drives brain aging and cognitive decline. Senotherapeutics, targeting senescent cells or their secretions, show promise in preclinical models for enhancing brain health and function.

Keywords:
brain aginginflammationneurodegenerative diseasepro-inflammatory secretory profile (SASP)senolyticssenomorphicssenotherapeutics

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Area of Science:

  • Neuroscience
  • Gerontology
  • Cell Biology

Background:

  • Brain aging involves cellular dysfunction and inflammation.
  • Cellular senescence, marked by a pro-inflammatory secretory profile (SASP), contributes to cognitive decline.
  • Senescent cells accumulate with age, impacting brain health.

Purpose of the Study:

  • To review senotherapeutics as a strategy for mitigating brain aging.
  • To explore senolytics and senomorphics for cognitive enhancement.
  • To summarize evidence on senotherapeutics in aging and neurodegenerative disease models.

Main Methods:

  • Review of preclinical studies on senotherapeutics in aged animal models.
  • Analysis of early-phase clinical trials for senolytics in Alzheimer's disease.
  • Discussion of challenges in senotherapeutic drug development for the brain.

Main Results:

  • Senotherapeutics reduce neuro-inflammation and improve synaptic plasticity in aged models.
  • Preclinical studies demonstrate enhanced cognitive function with senotherapeutic interventions.
  • Early clinical trials are investigating senolytics for Alzheimer's disease.

Conclusions:

  • Senotherapeutics offer a promising approach to combat age-related cognitive decline.
  • Combination therapies and personalized approaches may optimize senotherapeutic efficacy.
  • Further research is needed to address challenges in brain drug delivery and safety.