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Radioprotective and Radiomitigative Effects of Resveratrol in Radiation-Induced Reproductive Toxicity in Male Mice
Małgorzata M Dobrzyńska1, Aneta Gajowik1
1Department of Radiation Hygiene and Radiobiology, National Institute of Public Health NIH-National Research Institute, 24 Chocimska Street, 00-791 Warsaw, Poland.
Toxics
|December 24, 2025
Summary
Resveratrol (RSV) supplementation can protect male mice from radiation-induced sperm damage, improving sperm count and mitigating DNA injury. However, RSV is toxic during long-term irradiation recovery.
Area of Science:
- Reproductive biology
- Radiation oncology
- Pharmacology
Background:
- Free radical-scavenging agents can modify radiation effects.
- Resveratrol (RSV) possesses antioxidant properties.
- Investigating RSV's role in radiation protection and mitigation is crucial.
Purpose of the Study:
- To evaluate resveratrol's impact on sperm count and quality in mice exposed to X-irradiation.
- To determine optimal timing for RSV supplementation (pre-irradiation, during, or post-irradiation).
- To assess RSV's effects on DNA damage in germ cells.
Main Methods:
- Mice were exposed to X-irradiation with varying doses and timings.
- Resveratrol (RSV) was administered at different intervals relative to irradiation.
- Sperm count, quality, and DNA damage were assessed.
Main Results:
- Irradiation significantly decreased sperm count.
- RSV supplementation 24 hours post-irradiation increased sperm count.
- RSV mitigated DNA damage when combined with low-dose irradiation but increased it with high doses.
- RSV supplementation during recovery was toxic and worsened sperm parameters.
Conclusions:
- Resveratrol counteracts radiation-induced germ cell death and improves sperm count.
- RSV can act as a radioprotector (before/during exposure) or radiomitigator (after exposure).
- Supplementation during recovery is not recommended due to toxicity; timing is critical for efficacy.
