Topical Ozone as an Adjuvant Therapy in Wound Management: An Integrative Review

Area of Science:

• Wound Healing Research
• Ozone Therapy Applications
• Regenerative Medicine

Background:

• Chronic wound management presents significant clinical challenges.
• Ozone therapy is explored as an adjuvant treatment due to its antimicrobial, anti-inflammatory, and regenerative properties.

Purpose of the Study:

• To critically analyze the therapeutic effects of ozone in wound treatment.
• To review routes of administration, benefits, and limitations of ozone therapy for wounds.

Main Methods:

• Integrative review following Joanna Briggs Institute methodology and PRISMA 2020 guidelines.
• Searched SCOPUS, CINAHL Ultimate, MEDLINE Ultimate, and MedicLatina databases.
• Included primary studies on adult wound treatment with ozone, assessing methodological quality.

Main Results:

• Nine reports (2019-2025) showed clinical benefits: accelerated healing, pain reduction, infection control.
• Ozone was applied as ozonated water, ozonated olive oil, and gaseous ozone.
• Heterogeneity in ozone concentration, frequency, and duration was noted; methodological quality was moderate to high.

Conclusions:

• Ozone therapy shows potential as an adjuvant treatment for specific wounds.
• Limited study quality, lack of standardized protocols, and methodological variability restrict generalizability.
• More robust clinical trials are necessary to support widespread clinical implementation.