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MicroRNAs in Breast Cancer Bone Metastasis Formation and Progression: An Overview on Recent Progress in This Research

Margherita Puppo1

  • 1IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy.

Non-Coding RNA
|December 24, 2025
PubMed

Insights

MicroRNAs (miRNAs) play a key role in the bone metastasis of breast cancer (BC). This review covers recent findings on miRNAs and their targets in BC bone metastasis and discusses their potential as biomarkers or therapeutics.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Bone metastasis is a frequent and severe complication of advanced breast cancer (BC), associated with limited treatment options and poor prognosis.
  • MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation, which can be released into circulation and act as intercellular communicators.
  • miRNAs are increasingly recognized for their critical roles in the metastatic progression of BC to bone.

Purpose of the Study:

  • To review recent findings on the role of miRNAs and their mRNA targets in driving BC bone metastasis.
  • To discuss the potential clinical applications of miRNAs as biomarkers or therapeutic agents for BC bone metastasis.

Main Methods:

  • Literature review of recent studies on miRNAs and BC bone metastasis.
  • Analysis of miRNA-mRNA interactions implicated in BC bone metastasis.
  • Discussion of clinical potential for miRNA-based diagnostics and therapeutics.

Main Results:

  • miRNAs are pivotal regulators in the process of BC bone metastasis.
  • Specific miRNAs and their mRNA targets have been identified that promote BC bone metastasis.
  • Circulating miRNAs show promise as biomarkers for BC bone metastasis.

Conclusions:

  • miRNAs are significant drivers of BC bone metastasis.
  • Targeting miRNAs or utilizing them as biomarkers holds potential for improving BC patient outcomes.
  • Further research is warranted to translate these findings into clinical practice.
Keywords:
biomarkersbone metastasisbreast cancermiRmiRNAmicroRNAncRNAosteoblastosteoclasttarget therapy

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