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Action Potentials01:41

Action Potentials

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Toward Subcellular Action Potential Detection with Nanodiamond Quantum Magnetometry.

Azmath Fathima1,2, Peker Milas1,3, Sheikh Mahtab1

  • 1Department of Physics and Engineering Physics, Morgan State University, Baltimore, MD 21251, USA.

Nanomaterials (Basel, Switzerland)
|December 24, 2025
PubMed
Summary

Nitrogen vacancy (NV) nanodiamonds serve as non-bleaching fluorescent markers in mouse brain cells. These nanodiamonds show potential for subcellular action potential recording, advancing quantum sensing applications.

Keywords:
NV diamondODMRaction potentialsquantum sensing

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Area of Science:

  • Quantum sensing
  • Nanotechnology
  • Neuroscience

Background:

  • Nitrogen vacancy (NV) defects in diamond are powerful quantum sensors for various physical quantities.
  • NV defects in bulk diamond have enabled action potential detection in biological systems.
  • Nanodiamonds (NDs) with NV defects are non-bleaching fluorescent markers, but subcellular action potential recording remains unachieved.

Purpose of the Study:

  • To investigate the feasibility of using nanodiamonds (NDs) for subcellular imaging and sensing in mouse brain cells.
  • To assess NDs' potential for action potential recording at the subcellular level.

Main Methods:

  • Confocal imaging was used to track the cellular uptake of NDs of various sizes (10-140 nm).
  • Photoluminescence (PL) stability was evaluated over 5-hour imaging sessions.
  • Optically detected magnetic resonance (ODMR) was employed to detect magnetic fields using NDs within cell solutions.

Main Results:

  • 10 nm and 60 nm NDs diffused into mouse brain cells within 30 minutes without surface modification.
  • NDs exhibited stable, non-bleaching photoluminescence over extended imaging periods.
  • ODMR successfully detected millitesla-level magnetic fields with NDs in cellular environments.

Conclusions:

  • NDs are effective, photostable fluorescent markers for mouse brain cells.
  • NDs demonstrate potential for future applications in subcellular action potential recording.
  • This work advances the use of quantum sensing tools in neuroscience research.